Nanocarbon Materials for Photodynamic Therapy and Photothermal Therapy

Author(s): Qian Li, Hong Ruan and Hongguang LiPages 58-64 (7) Abstract: Photodynamic therapy (PDT) and photothermal therapy (PTT) are two kinds of methodologies that can be applied to the treatment of cancer. They own some advantages over the existing strategies including chemo- and radiotherapy but at the same time, are also facing big challenges. During the past decades,...

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The Oral and Intranasal Delivery of Propofol Using Chitosan Amphiphile Nanoparticles

Author(s): Ijeoma F. Uchegbu, Marie-Christine Jones, Federica Corrente, Lisa Godfrey, Davide Laghezza, Maria Carafa, Per Holm and Andreas G. SchatzleinPages 65-74 (10) Abstract: The intravenous anaesthetic propofol acts on gamma amino butyric acid A (GABAA) receptors in the brain. Propofol is often used as a procedural sedative and is also effective (at sub-anaesthetic...

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Improved Oral Bioavailability of Cefuroxime Axetil Utilizing Nanosuspensions Developed by Media Milling Technique

Author(s): Yomesh Patel, Aditi Poddar and Krutika K. SawantPages 75-86 (12) Abstract: Cefuroxime axetil is a Class IV drug as per the Biopharmaceutical Classification System. It is a prodrug of Cefuroxime which is practically insoluble in water with a log P of 3.8. The absolute bioavailability of cefuroxime axetil, determined after intravenous injection of 1 g of cefuroxime...

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Formulation Studies on Novel Self-Solidifying Self-Nanoemulsifying Drug Delivery Systems of Nebivolol Hydrochloride

Author(s): Nilesh M. Khutle and Vijaya C.Pages 87-100 (14) Abstract: Nebivolol HCl (NBL) a third generation beta blocker poses lack of oral bioavailability (12%) owing to its low solubility and first pass biotransformation in liver. The present research was undertaken to prepare solid Selfnanoemulsifying drug delivery system (S-SNEDDS) of NBL which will present NBL at molecular...

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Stable Indomethacin Dispersions in Water from Drug, Ethanol, Cationic Lipid and Carboxymethyl-Cellulose

Author(s): Eliete G. Lima, Luciano R. Gomes and Ana M. Carmona-RibeiroPages 126-135 (10) Abstract: Background: The problem of formulating hydrophobic drugs in aqueous solutions is addressed from the point of view of nanotechnology. Nanoparticles (NPs) can incorporate high drug-to-carrier molar ratios with optimal drug dispersion and colloidal stabilization in water...

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